Per Svenningsson
Co-PI (Core Leadership)
Karolinska Institutet
Per is a Professor of Neurology at the Karolinska Institutet, Sweden. He studied monoamine-mediated signal transduction as a postdoctoral fellow with the Nobel laureate Paul Greengard at the Rockefeller University. He is member of the International Executive Committee of the Movement Disorder Society. Among his awards is the Arvid Carlsson Prize and the Allan D Bass Prize lecture at the Vanderbilt University.
Teams
Themes
Tags
Motor symptoms
Gut-brain axis
Alpha-synuclein
Circuits and symptoms
Artificial intelligence
Structure guided drug design
Recent ASAP Preprints & Published Papers
Multi-omics reveal critical differentiation target for Parkinson’s Disease-vulnerable midbrain dopaminergic neurons
Parkinson’s disease (PD) is characterized by the progressive loss of midbrain dopaminergic (mDA) neurons, leading to severe debilitating motor impairment. Recent single-cell analyses have revealed that specific mDA subpopulations, such as SOX6⁺ AGTR1⁺ neurons, are most vulnerable to degeneration. Current human pluripotent stem cell differentiation protocols fail to selectively generate…
Leveraging animal models to understand non-motor symptoms of Parkinson's disease
Parkinson's disease is diagnosed based on motor symptoms, but non-motor symptoms of the disease, such as cognitive impairment, autonomic dysfunction, hyposmia, sleep disorders, and psychiatric disorders heavily impact patient and caregiver quality of life. It has proven challenging to faithfully reproduce and quantify these non-motor phenotypes. Indeed, many non-motor signs…
