Background pattern of a brain with neural connections

Team Hurley

Mechanisms of Mitochondrial Damage Control by PINK1 and Parkin

2020-Present

The purpose of this project is to figure out how PINK1, parkin and mitophagy work together to prevent disease. Once we know how they work together, we hope to figure out how to make them work faster and better, so that we can prevent Parkinson’s disease from ever starting. We think of PINK1, parkin and the proteins of mitophagy as nanomachines. We call our type of research “mechanistic” because it seeks to understand how these machines work. We rely heavily on the most powerful light and electron microscopes available, and we also use genome engineering of stem cells to make versions of neurons that are easier to study.

Tags
Mitochondria Parkin (PARK2) PINK1

Project Highlights

Contributions

Here is an overview of how this team’s article findings have contributed to the PD field as of June 2025. There are two different categorizations of these contributions – one by impact to the PD community and a second by scientific category.

Impact

Category

Accolades

Members of the team have been recognized for their contributions.

Team Hurley

Open Science Champions

Dorotea Fracchiolla

Awards

2023 Collaborative Meeting

COSA Prize Winners 2024

Network Spotlights

Dorotea Fracchiolla, Bishal Basak

In the News

Our Research Teams

Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.