Team Kordower

We will test the hypothesis that the induction of co-pathologies will provide more construct and face validity in the context of human disease, and thus be a superior model for the evaluation of future novel therapies. Herein we propose to create novel nonhuman primate models of co-pathology and inflammation through treatment with alpha synuclein preformed fibrils, AAV-tau, and beta amyloid via aging and transgenesis. We will validate these models by comparing our findings to inflammatory processes seen in human brain samples and refine exploration of the mechanisms involved by blocking these pathologies in mice and nonhuman primates using specific immunotherapies.