Background pattern of a brain with neural connections

Team Sulzer

Adaptive immunity in the etiology and progression of Parkinson’s disease

2020-Present

We propose that, in PD, these activated T cells mistake the body’s normal nerve cells as foreign invaders (autoimmunity) and this error is critical in the initiation of PD. The interactions of T cells with nerve cells underlies the loss of specific neurons in PD, including substantia nigra dopamine neurons. We will determine the steps that occur in T cell activation in PD by examining T cells in blood from PD patients and healthy controls, and in the gut and brain of new mouse models of PD. To examine if these cell types are in human brain, we have developed new methods to detect signals in specific cells in autopsies of PD patients.

Tags
Adaptive immunity Alpha-synuclein PD progression T cells

Project Highlights

Contributions

Here is an overview of how this team’s article findings have contributed to the PD field as of June 2025. There are two different categorizations of these contributions – one by impact to the PD community and a second by scientific category.

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