Background pattern of a brain with neural connections
Erinc Halliacli

Erinc Halliacli

Co-PI (Core Leadership)

Brigham and Women's Hospital

Erinc Hallacli is an instructor in neurology in Vikram Khurana’s lab at Brigham and Womens’ Hospital. He was trained as a molecular biologist and geneticist as an undergraduate. He received an MSc degree from Heidelberg University, Germany for his work on the relationship between RNA export and transcription conducted in Ed Hurt lab. He studied genome-wide chromatin regulators with Asifa Akhtar in EMBL and Max Planck Institute for his doctoral thesis. He started his research on RNA binding proteins as prions in Susan Lindquist lab. He has been working on the relationship between RNA binding proteins and alpha-synuclein in Dr.Khurana lab. He is currently an instructor at Harvard Medical School and holds several awards including EMBO and HFSP fellowships.

Teams

Krichevsky

Themes

PD Heterogeneity

Tags

PD heterogeneity: aging iPSC neurons Non-coding RNA in situ RNA analytics Alpha-synuclein

Recent ASAP Preprints & Published Papers

Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies

Whether neurodegenerative diseases linked to misfolding of the same protein share genetic risk drivers or whether different protein-aggregation pathologies in neurodegeneration are mechanistically related remains uncertain. Conventional genetic analyses are underpowered to address these questions. Through careful selection of patients based on protein aggregation phenotype (rather than clinical diagnosis) we…

The Parkinson’s disease protein alpha-synuclein is a modulator of processing bodies and mRNA stability

Alpha-synuclein (αS) is a conformationally plastic protein that reversibly binds to cellular membranes. It aggregates and is genetically linked to Parkinson’s disease (PD). Here, we show that αS directly modulates processing bodies (P-bodies), membraneless organelles that function in mRNA turnover and storage. The N terminus of αS, but not other…

Team Krichevsky

Anna Krichevsky

Anna Krichevsky

Lead PI (Core Leadership)
YuHong Fu

YuHong Fu

Co-PI (Core Leadership)
Erinc Halliacli

Erinc Halliacli

Co-PI (Core Leadership)
Glenda Halliday

Glenda Halliday

Co-PI (Core Leadership)
Vikram Khurana

Vikram Khurana

Co-PI (Core Leadership)

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