Michele Vendruscolo
Co-PI (Core Leadership)
University of Cambridge
Michele Vendruscolo is professor of biophysics in the Department of Chemistry, University of Cambridge. He is director of the Chemistry of Health Laboratory and co-director of the Centre for Misfolding Diseases. His research concerns the molecular origins of protein misfolding diseases and the development of diagnostic and therapeutic approaches for these diseases.
Recent ASAP Preprints & Published Papers
The diversity of SNCA transcripts in neurons, and its impact on antisense oligonucleotide therapeutics
The role of the SNCA gene locus in driving Parkinson’s disease (PD) through rare and common genetic variation is well-recognized, but the transcriptional diversity of SNCA in vulnerable cell types remains unclear. We performed SNCA long-read RNA sequencing in human dopaminergic neurons and show that annotated SNCA transcripts account for…
RASP: Optimal single fluorescent puncta detection in complex cellular backgrounds
Super-resolution and single-molecule microscopies have been increasingly applied to complex biological systems. A major challenge of these approaches is that fluorescent puncta must be detected in the low signal, high noise, heterogeneous background environments of cells and tissue. We present RASP, Radiality Analysis of Single Puncta, a bioimaging-segmentation method that…
