Miratul Muqit
Co-PI (Core Leadership)
University of Dundee
Dr Miratul Muqit is a Professor in the MRC Protein Phosphorylation and Ubiquitylation Unit, University Dundee, and a Wellcome Trust Senior Fellow. He studied Medicine at the University of Edinburgh and was a graduate student with Nicholas Wood at UCL Institute of Neurology where he contributed to the discovery of PINK1 mutations as a cause of Parkinson’s. He was elected Fellow of the Royal Society of Edinburgh in 2020.
Teams
Themes
Tags
Aging
RNA Single Cell
Dopaminergic neurons
Postmortem
Spatial Transcriptomics
Mouse
Alpha-synuclein
Recent ASAP Preprints & Published Papers
Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress
Cells have evolved organelle-specific responses to maintain protein homeostasis (proteostasis). During proteostatic stress, mitochondria downregulate translation and enhance protein folding, yet the underlying mechanisms remain poorly defined. Here, we employed cryo-electron tomography to observe the structural consequences of mitochondrial proteostatic stress within human cells. We detected protein aggregates within the…
Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
Mutations in Leucine-rich repeat kinase 2 (LRRK2) and PTEN-induced kinase 1 (PINK1) are associated with familial Parkinson’s disease (PD). LRRK2 phosphorylates Rab guanosine triphosphatase (GTPases) within the Switch II domain while PINK1 directly phosphorylates Parkin and ubiquitin (Ub) and indirectly induces phosphorylation of a subset of Rab GTPases. Herein we…
