Samantha Gruenheid
Co-PI (Core Leadership)
McGill University
Samantha Gruenheid is a Professor and Associate Chair in the Department of Microbiology and Immunology at McGill. As a graduate student with Philippe Gros at McGill, she characterized the Nramp family of proteins, including the cloning mouse Nramp 2 (DMT-1). She undertook postdoctoral studies in bacterial pathogenesis with Brett Finlay at the University of British Columbia, and was recruited back to a Faculty position at McGill in 2005.
Teams
Themes
Tags
Neural circuitry
AAV (Adenoassociated Virus)
Basal Ganglia
Recent ASAP Preprints & Published Papers
Characterizing enteric neurons in dopamine transporter (DAT)-Cre reporter mice reveals dopaminergic subtypes with dual-transmitter content
The enteric nervous system (ENS) comprises a complex network of neurons whereby a subset appears to be dopaminergic although the characteristics, roles, and implications in disease are less understood. Most investigations relating to enteric dopamine (DA) neurons rely on immunoreactivity to tyrosine hydroxylase (TH)—the rate-limiting enzyme in the production of…
Microbes and Parkinson’s Disease: from associations to mechanisms
Several microbes, including viruses, bacteria, and fungi, have been associated with an increased risk of PD in humans. Microbial infections can induce similar common pathways that are associated with PD, including systemic inflammatory responses, α-synuclein misfolding, and disruption of mitochondria. PD-associated gene mutations can impact host–microbe interactions, suggesting that even…
