Background pattern of a brain with neural connections
Lilia Rodriguez

Lilia Rodriguez

Project Manager

Université de Montréal

Lilia is an experienced researcher with excellent understanding of basic neurobiology of neurodegenerative diseases and mechanisms of neurodegeneration. She worked on the prion hypothesis in Alzheimer’s disease (studying tau protein) and in Parkinson’s disease (studying alpha synuclein) and have an in-depth understanding on the common pathological mechanisms in these two diseases.

Teams

Desjardins

Themes

Neuro-Immune Interactions

Tags

VPS35 Parkin (PARK2) T cells Autoimmunity PINK1 LRRK2

Recent ASAP Preprints & Published Papers

High-Yield Monocyte/Macrophage Differentiation from hiPSC

Here, a highly efficient method for differentiating monocytes/macrophages from hiPSC is described. The process utilizes commercially-available materials to derive CD34+ progenitor cells that are apically released from a hemogenic endothelium. Subsequently, the hemogenic endothelium gives rise to highly pure (>95%), CD34-CD14+ monocytes in 19-23 days and yields more monocytes by day 35 when compared to previous methods. These monocytes are further differentiated to macrophages after 7 days. The efficient workflow and increase in monocyte output boost feasibility for high throughput studies and enables clinical-scale iPSC-derived manufacturing processes.

Team Desjardins

Michel Desjardins

Michel Desjardins

Lead PI (Core Leadership)

Louis-Eric Trudeau

Louis-Eric Trudeau

Co-PI (Core Leadership)

Heidi McBride

Heidi McBride

Co-PI (Core Leadership)

Samantha Gruenheid

Samantha Gruenheid

Co-PI (Core Leadership)

Janelle Drouin-Ouellet

Janelle Drouin-Ouellet

Co-PI (Core Leadership)

Lilia Rodriguez

Lilia Rodriguez

Project Manager

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