James Evans

Neuroinflammation, Genomic Regulation, and Systemic Drivers

James is a postdoctoral research fellow at the Francis Crick Institute and UCL Queen Square Institute of Neurology. James’ work focuses on using induced pluripotent stem cell models, advanced imaging techniques, and transcriptomics, to understand how glia influence the onset and progression of Parkinson’s disease.

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The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1

Mutations in GBA1 cause Gaucher disease and are the most important genetic risk factor for Parkinson’s disease. However, analysis of transcription at this locus is complicated by its highly homologous pseudogene, GBAP1. We show that >50% of short RNA-sequencing reads mapping to GBA1 also map to GBAP1. Thus, we used...

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James Evans

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