Alexandra Kazanova

Alexandra Kazanova

Neuroinflammation, Genomic Regulation, and Systemic Drivers

Alex is a research associate in the Samantha Gruenheid lab in the Department of Microbiology and Immunology, McGill University.

Tags
AutoimmunityLRRK2Parkin (PARK2)PINK1T cellsVPS35

Home Team

Team Desjardins

Host Team

Team Sulzer

Project Highlights

Cell-autonomous and non-cell-autonomous drivers of dopamine neuron vulnerability in Parkinson’s disease

The motor symptoms of Parkinson’s disease are linked to age-dependent degeneration of dopamine neurons. Traditionally, the loss of these neurons has been thought to stem mainly from cell-autonomous cellular dysfunctions. However, there is growing evidence suggesting it could result from complex interactions between cell-autonomous and non-cell-autonomous mechanisms. This review examines...

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