CRN Research Community Alyssa O’Grady Alyssa O’Grady Project Manager Teams PPMI Tags Biomarkers Genetics Clinical trials Recent ASAP Preprints & Published Papers Parkinson's Progression Markers Initiative: A Milestone-Based Strategy to Monitor PD Progression Challenge: Identifying a meaningful progression metric for Parkinson's disease (PD) that reflects heterogeneity remains a challenge. Objective: To assess the frequency and baseline predictors of progression to clinically relevant motor and non-motor PD milestones. Methods: Using data from the Parkinson's Progression Markers Initiative (PPMI) de novo PD cohort, we monitored… Team PPMI Ken Marek Lead PI (Core Leadership) Kalpana Merchant Co-PI (Core Leadership) Brit Mollenhauer Co-PI (Core Leadership) Kathleen Poston Co-PI (Core Leadership) Tatyana Simuni Co-PI (Core Leadership) Alyssa O’Grady Project Manager