Eric Herrmann

Eric Herrmann

Alpha-Synuclein Pathology, Aggregation Kinetics, and Disease Propagation

Eric is a postdoctoral fellow in the Department of Molecular and Cellular Biology at the University of California, Berkeley. He studied the regulation of small GTPases on membranes as a graduate student with Daniel Kümmel at the University of Münster in Germany.

Tags
MitochondriaParkin (PARK2)PINK1

Home Team

Team Hurley

Host Team

Team Alessi

Project Highlights

Cathepsin-dependent amyloid formation drives mechanical rupture of lysosomal membranes

Lysosomal membrane integrity is essential for cellular homeostasis, and its failure drives lysosomal storage disorders (LSD) and neurodegeneration. The dipeptide L-leucyl-L-leucine methyl ester (LLOMe) is widely used to model lysosomal damage, yet its mechanism remains poorly understood. The prevailing view holds that LLOMe polymerizes into membrane-permeabilizing peptide chains within the...

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