Jonathan Brenton

Jonathan Brenton

Neuronal Resilience and Transcriptional Regulatory Programs

Jonathan is a Research Associate in the Department of Genetics and Genomic Medicine at University College London, working under Mina Ryten and John Hardy. He studied the genetic and synaptic correlates in a dietary model of ageing at University College London for his doctoral project.

Tags
Alpha-synucleinAnimal modelsClinical measuresGenetic targetsGlycosphingolipidsLysosomesMitophagyPathology

Home Team

Team Hardy

Host Team

Team Alessi

Project Highlights

GPNMB is a biomarker for lysosomal dysfunction and is secreted via LRRK2-modulated lysosomal exocytosis

Genome-wide association studies have identified *Glycoprotein Nmb* (*GPNMB*) as a risk factor for Parkinson’s Disease. The risk allele increases *GPNMB* transcription and GPNMB protein levels in the CSF highlighting GPMNB as a potential biomarker for Parkinson’s Disease. However, a lack of knowledge of GPNMB’s function and mechanism of secretion have hindered an interpretation of...

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