Background pattern of a brain with neural connections
Joseph Lyons

Joseph Lyons

Co-PI (Core Leadership)

Aarhus University

Joe is an Assistant Professor in the Department of Molecular Biology and Genetics, Aarhus University. He studied lipid phase behaviour and membrane protein structure determination from synthetic membranes as a graduate student with Prof. Martin Caffrey at University of Limerick and Trinity College Dublin, Ireland. Postdoctoral studies with Prof. Poul Nissen culminated in the first structures of a lipid flippase using single particle cryo-electron microscopy.

Teams

Vangheluwe

Themes

PD Functional Genomics

Tags

Alpha-synuclein Lysosomal dysfunction GBA1 ATP13A2 Polyamine ATP10B

Recent ASAP Preprints & Published Papers

Functional characterization of ATP13A2 variants associated with distinct neurodegenerative disorders

ATP13A2 is a late endolysosomal transporter that exports the polyamines spermine and spermidine from the organellar lumen to the cytosol. Loss-of-function variants in ATP13A2 are causative for Kufor-Rakeb syndrome (KRS, a recessive juvenile-onset parkinsonism with dementia) and have also been identified in early-onset PD (EOPD) and hereditary spastic paraplegia (HSP).…

Team Vangheluwe

Peter Vangheluwe

Peter Vangheluwe

Lead PI (Core Leadership)
Veerle Baekelandt

Veerle Baekelandt

Co-PI (Core Leadership)
Joel Blanchard

Joel Blanchard

Co-PI (Core Leadership)
Joseph Lyons

Joseph Lyons

Co-PI (Core Leadership)
Ellen Sidransky

Ellen Sidransky

Co-PI (Core Leadership)
Veronique Daniels

Veronique Daniels

Project Manager

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