Odetta Antico
Cellular Quality Control and Organelle Dysfunction
Odetta is a neurobiologist in the MRC Protein Phosphorylation and Ubiquitylation Unit (PPU), University of Dundee. She obtained her master degree at University of Turin where she studied the role of metabolism and the effect of insulin-sensitizing drugs in a transgenic mouse model of Alzheimer’s disease (APP/PS1). Then, she pursued her interest in understanding the role of insulin resistance in Alzheimer-related dementias, and moved to the Italian Institute of Technology (IIT) to work on a project aimed at investigating the action of metformin in a relevant transgenic mouse of tauopathy (P301S-tau). Furthermore, she led a research project aimed at developing gene therapy strategies to degrade toxic aggregates of α-synuclein at San Raffaele Scientific Institute in Milan. This involved microglia reconstitution through transplantation of hematopoietic stem cells (HSC) into (A53T) α-synuclein overexpressing mice, as a potential therapeutic approach for Parkinson’s disease.
