Background pattern of a brain with neural connections
Peter Vangheluwe

Peter Vangheluwe

Lead PI (Core Leadership)

KU Leuven

Peter Vangheluwe is an Associate Professor in the Department of Cellular and Molecular Medicine at KU Leuven in Belgium, and is head of the Laboratory of Cellular Transport Systems. Using biochemical and molecular cell biology approaches, he characterizes new P-type transport ATPases that regulate polyamine homeostasis and lipid distribution in the cell. He discovered that ATP13A2/PARK9 works as a lysosomal polyamine transporter, and that ATP10B operates as a lysosomal glucosylceramide exporter. He published >60 peer-reviewed publications and received two awards by the Queen Elisabeth Foundation for Neurosciences in Belgium.

Teams

Vangheluwe

Themes

Circuitry and Brain-Body Interactions

Recent ASAP Preprints & Published Papers

Loss of the lysosomal lipid flippase ATP10B leads to progressive dopaminergic neurodegeneration and Parkinsonian motor deficits

ATP10B, a transmembrane lipid flippase located in late endosomes and lysosomes, facilitates the export of glucosylceramide and phosphatidylcholine by coupling this process to ATP hydrolysis. Recently, loss-of-function mutations in the ATP10B gene have been identified in Parkinson's disease patients, pointing to ATP10B as a candidate genetic risk factor. Previous studies…

Kufor-Rakeb Syndrome-Associated Psychosis: A Novel Loss-of-Function ATP13A2 Variant and Response to Treatment

iallelic (autosomal recessive) pathogenic variants in ATP13A2 cause a form of juvenile-onset parkinsonism, termed Kufor-Rakeb syndrome. In addition to motor symptoms, a variety of other neurological and psychiatric symptoms may occur in affected individuals, including supranuclear gaze palsy, spasticity, and cognitive decline. Although psychotic symptoms are often reported, response to…

Team Vangheluwe

Peter Vangheluwe

Peter Vangheluwe

Lead PI (Core Leadership)
Veerle Baekelandt

Veerle Baekelandt

Co-PI (Core Leadership)
Joel Blanchard

Joel Blanchard

Co-PI (Core Leadership)
Joseph Lyons

Joseph Lyons

Co-PI (Core Leadership)
Ellen Sidransky

Ellen Sidransky

Co-PI (Core Leadership)
Veronique Daniels

Veronique Daniels

Project Manager

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