Weiqiang Liu

Weiqiang Liu

Neuronal Resilience and Transcriptional Regulatory Programs

Weiqiang Liu is a post-doctoral research fellow in Dr. Dong’s lab in the Department of Neurology at Yale School of Medicine, Yale University. Weiqiang received his Ph.D. in Ecology from the Institute of Zoology, Chinese Academy of Sciences (2018-2024). During his Ph.D. training, his main work involved using comparative transcriptomics and evolutionary genomics to explore how animals can have roughly similar sequences yet vastly different lifespans (EMBO Journal, 2023; Nature Communications, 2023).

Tags
GWASPD progressionRNA-seq

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Project Highlights

Single cell eQTL mapping reveals convergent glial–neuronal risk architecture in Parkinson's disease

Synucleinopathies affect 15 million people and are classically divided into neuronal (Parkinson's disease(PD), dementia with Lewy bodies) and glial (multiple system atrophy) disorders. Here we challenge this dichotomy. We functionally fine-map 90 PD GWAS signals across nine cell types in cortex and substantia nigra using disease-context, population-scale single-nucleus eQTL meta-analysis...

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