Background pattern of a brain with neural connections

Team Awatramani

Defining separate rewarding and aversive dopaminergic circuits and their role in Parkinson’s disease associated pain

2026-Present

Parkinson’s disease (PD) motor symptoms result from the degeneration of dopamine (DA)-producing neurons in the substantia nigra, but the cellular origins for highly comorbid non-motor symptoms such as pain are poorly understood. We hypothesize that the ventral tegmental area (VTA) contains molecularly separable reward and aversive signaling DA neurons, and that the relative resistance of DA neurons in mesencephalic pain pathways to pathogenesis, leads to aberrant pain states in PD patients. Such an imbalance in VTA DA reward and aversion signaling may also be relevant for other non-motor PD symptoms like depression.

Tags
Animal modelsNon-motor symptomsPathophysiology

Project Highlights

Contributions

Here is an overview of how this team’s article findings have contributed to the PD field as of June 2025. There are two different categorizations of these contributions – one by impact to the PD community and a second by scientific category.

Stay tuned—this is where the team’s scientific contributions will be shared.

Accolades

Members of the team have been recognized for their contributions.

Open Science Champions

Maite Azcorra, Zachary Gaertner

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