Background pattern of a brain with neural connections

Team GP2

Uncovering the genetic architecture of Parkinson’s disease

Team GP2 provides CRN researchers with a direct connection to the Global Parkinson’s Genetics Program (GP2), an international collaborative effort aimed at making transformational progress in Parkinson’s disease (PD) genetics.

The existing infrastructure of GP2 can be leveraged by CRN Teams, for example to centralize and standardize genotyping and whole genome sequencing (WGS) of Parkinson’s disease tissues and cell lines. Moreover, teams can utilize GP2 expertise to identify novel genetic links for targets of interest to PD.

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Cornelis Blauwendraat

Cornelis Blauwendraat

Lead PI (Core Leadership)

Andrew Singleton

Andrew Singleton

Lead PI (Core Leadership)

Laurel Screven

Laurel Screven

Project Manager

J Solle

J Solle

Project Manager

Project Highlights

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GenoTools: an open-source Python package for efficient genotype data quality control and analysis

GenoTools, a Python package, streamlines population genetics research by integrating ancestry estimation, quality control, and genome-wide association studies capabilities into efficient pipelines. By tracking samples, variants, and quality-specific measures throughout fully customizable pipelines, users can easily manage genetics data for large and small studies. GenoTools' “Ancestry” module renders highly accurate...

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