Background pattern of a brain with neural connections

Team Greenamyre

Environmental exposures and PD heterogeneity: Mechanisms and therapeutic mitigation.

2026-Present

Using cell and animal models of PD-associated environmental toxicant exposures, this project will elucidate the biological processes that lead from exposure to neurodegeneration and, ultimately, to PD. By defining these pathological processes, we will identify “targets” for potential therapeutic mitigation of post-exposure toxicity. Importantly, the effects of age and sex will be investigated. We will also examine the extent to which rodent models of toxicant exposure reflect what happens, on a cell-by-cell basis, in the brains of human subjects with sporadic PD. This multi-pronged approach will improve our understanding of PD causation and heterogeneity and will identify novel therapeutic strategies.

Tags
Animal modelsGene-environment interactionsOxidative stressPesticidesTranscriptomics

Contributions

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Accolades

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In the News

Decoding the Blueprint: Advancing Personalized Parkinson’s Treatments

Decoding the Blueprint: Advancing Personalized Parkinson’s Treatments

05/21/2026 — In our community, we often hear: “If you’ve met one person with Parkinson’s, you’ve met one person with Parkinson’s.” This isn’t just an adage — it’s a biological reality. This radical variability is exactly what makes the disease so difficult to outsmart. We’ve learned that a puzzle this fragmented cannot be solved with a single, broad stroke. Our goal isn’t to find one answer for everyone, but the right answer for the right person at the right time.

Aligning Science Across Parkinson’s and The Michael J. Fox Foundation Expand Global Research Initiative with $261M Investment Toward Personalized Treatments

Aligning Science Across Parkinson’s and The Michael J. Fox Foundation Expand Global Research Initiative with $261M Investment Toward Personalized Treatments

04/28/2026 — Today, Aligning Science Across Parkinson’s (ASAP), in partnership with The Michael J. Fox Foundation for Parkinson’s Research (MJFF), announced $261 million in new grant funding for the Collaborative Research Network (CRN) to map the biological blueprint of Parkinson’s disease and build a standardized toolkit of global research resources that are needed to turn discoveries into treatments.

Our Research Teams

Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.