Contributions
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Accolades
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Team Greenamyre
Environmental exposures and PD heterogeneity: Mechanisms and therapeutic mitigation.
Using cell and animal models of PD-associated environmental toxicant exposures, this project will elucidate the biological processes that lead from exposure to neurodegeneration and, ultimately, to PD. By defining these pathological processes, we will identify “targets” for potential therapeutic mitigation of post-exposure toxicity. Importantly, the effects of age and sex will be investigated. We will also examine the extent to which rodent models of toxicant exposure reflect what happens, on a cell-by-cell basis, in the brains of human subjects with sporadic PD. This multi-pronged approach will improve our understanding of PD causation and heterogeneity and will identify novel therapeutic strategies.
Tags
Animal modelsGene-environment interactionsOxidative stressPesticidesTranscriptomics
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Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.
