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Team Sharott
Defining the neural mechanisms underlying heterogeneity in sleep and circadian rhythm disturbances in Parkinson’s disease
Disturbances in sleep and daily rhythms are amongst of the most common symptoms of Parkinson’s disease (PD). In addition to their significant impact on wellbeing, these symptoms may accelerate and exacerbate other aspects of the disease and its progression. In this project, we aim to fully understand the brain activity that is associated with disrupted sleep and alertness, particularly in relation to the disruption of large-scale synchronization of populations of nerve cells that are necessary for sleep. By enhancing and suppressing these activities, we will test whether they cause sleep disturbances and can be targets for future treatment.
Tags
Circadian rhythmDBS/other stimulation interventionsElectrophysiologyMulti-electrode arrayNeurobiologyNeurodegenerationSleep disorders
Our Research Teams
Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.
