Background pattern of a brain with neural connections

Team Surmeier

Distributed circuit dysfunction underlying motor and sleep deficits in a progressive mouse model of Parkinson’s disease

2021-Present

Parkinson’s disease is a slow, progressive disorder that disrupts the function of brain circuits controlling movement and other aspects of daily living, including sleep. A key gap in our understanding is how brain circuitry is progressively altered from the earliest, prodromal disease stages to the time of clinical diagnosis. Filling this gap could lead to much earlier diagnosis and disease-modifying therapies. To this end, an internationally recognized team with complementary molecular, circuit tracing, physiological and behavioral expertise will interrogate a new mouse model that manifests both progressive motor and sleep deficits characteristic of PD.

Tags
Circuit dysfunction Mouse model PD progression Sleep disorders

Project Highlights

Contributions

Here is an overview of how this team’s article findings have contributed to the PD field as of June 2025. There are two different categorizations of these contributions – one by impact to the PD community and a second by scientific category.

Impact

Category

Accolades

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Our Research Teams

Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.