Background pattern of a brain with neural connections
Clare Parish

Clare Parish

Co-PI (Core Leadership)

Florey Institute of Neuroscience and Mental Health

Clare is a Professor at the Florey Institute of Neuroscience and Mental Health, The University of Melbourne. As a graduate student she studied compensatory mechanisms during PD progression and since then has focused her research on understanding and modelling neural development using stem cells. These stem cells have provided a valuable tool for her to improve the safety and efficacy of neural transplants, as more recently model and understand the disease.

Teams

Kirik

Themes

PD Functional Genomics

Tags

iPSCs (Induced pluripotent stem cells) Alpha-synuclein

Recent ASAP Preprints & Published Papers

Generation of human-induced pluripotent-stem-cell-derived cortical neurons for high-throughput imaging of neurite morphology and neuron maturation

A STAR protocol that describes how to differentiate cryopreserved human cortical neuronal progenitors into mature cortical neurons for high-throughput imaging analysis

Transgenic A53T mice have astrocytic a-synuclein aggregates in dopamine and striatal regions

This study aimed to determine whether astrocytes accumulate a-synuclein before or after neurons, the present study histologically assessed astrocytes and a-synuclein accumulation in the M83 A53T transgenic mouse model of Parkinson’s disease prior to significant neuronal a-synuclein accumulation.

Team Kirik

Deniz Kirik

Deniz Kirik

Lead PI (Core Leadership)

Lachlan Thompson

Lachlan Thompson

Co-PI (Core Leadership)

Clare Parish

Clare Parish

Co-PI (Core Leadership)

Jennifer Johnston

Jennifer Johnston

Co-PI (Core Leadership)

Glenda Halliday

Glenda Halliday

Collaborating PI

Courtney Wright

Courtney Wright

Project Manager

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Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.

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