Background pattern of a brain with neural connections
Glenda Halliday

Glenda Halliday

Lead PI (Core Leadership)

Co-PI (Core Leadership)

Collaborating PI

Macquarie University

Glenda is a Professor in the School of Medical Sciences, University of Sydney, and a Senior Leadership Fellow of the NHMRC. As a graduate student she mapped and compared the neurotransmitter systems in the brainstem across common laboratory species and primates (human and non-human) and has since mapped the distribution of disease pathology, identified immune and molecular mechanisms, and developed accessible biomarkers that link brain pathology to clinical expression. Among her awards is the 2021 Robert A. Pritzker Prize for Leadership in Parkinson’s Research, the 2017 C. David Marsden Lecture Award & 2025 President’s Distinguished Service Award from the International Parkinson’s & Movement Disorders Society, and a 2023 Companion of the Order of Australia.

Teams

Edwards Halliday Kirik Krichevsky Nelson Vila

Themes

Circuitry and Brain-Body Interactions PD Functional Genomics PD Heterogeneity

Tags

Non-motor symptoms iPSCs (Induced pluripotent stem cells) Alpha-synuclein Chemogenetics Pathology Catecholamines Noradrenaline Transcriptomics Electrophysiology PD progression in situ RNA analytics Machine learning Neurodegeneration Cognitive dysfunction/dementia Sleep disorders Locus coeruleus PD subtypes Non-coding RNA iPSC neurons PD heterogeneity: circuit biology PD heterogeneity: aging PD heterogeneity: co-pathology

Recent ASAP Preprints & Published Papers

Dementia with Lewy bodies and Parkinson disease dementia - the same or different and is it important?

Biological definitions of neurological diseases are now becoming a reality, although still in the research phase. This development will recategorize neurological diseases, providing objective diagnostics and the promise of therapeutics that target biological mechanisms — similar to the strategy that has proven successful in tumours and other conditions. In this…

CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology

Mitochondrial dysfunction is a hallmark of Parkinson’s disease (PD), but the mechanisms by which it drives autosomal dominant and idiopathic forms of PD remain unclear. To investigate this, we generated and performed a comprehensive phenotypic analysis of a knock-in mouse model carrying the T61I mutation in the mitochondrial protein CHCHD2…

Team Edwards

Robert Edwards

Robert Edwards

Lead PI (Core Leadership)
Zayd Khaliq

Zayd Khaliq

Co-PI (Core Leadership)
Talia Lerner

Talia Lerner

Co-PI (Core Leadership)
Ken Nakamura

Ken Nakamura

Co-PI (Core Leadership)
Alexandra Nelson

Alexandra Nelson

Co-PI (Core Leadership)
James Maas

James Maas

Project Manager

Team Halliday

Glenda Halliday

Glenda Halliday

Lead PI (Core Leadership)
John Crary

John Crary

Co-PI (Core Leadership)
Zane Jaunmuktane

Zane Jaunmuktane

Co-PI (Core Leadership)
Gabor Kovacs

Gabor Kovacs

Co-PI (Core Leadership)
Alexandra Young

Alexandra Young

Co-PI (Core Leadership)
Jasmin Galper

Jasmin Galper

Project Manager

Team Kirik

Deniz Kirik

Deniz Kirik

Lead PI (Core Leadership)
Glenda Halliday

Glenda Halliday

Co-PI (Core Leadership)
Jennifer Johnston

Jennifer Johnston

Co-PI (Core Leadership)
Clare Parish

Clare Parish

Co-PI (Core Leadership)
Lachlan Thompson

Lachlan Thompson

Co-PI (Core Leadership)
Courtney Wright

Courtney Wright

Project Manager

Team Krichevsky

Anna Krichevsky

Anna Krichevsky

Lead PI (Core Leadership)
YuHong Fu

YuHong Fu

Co-PI (Core Leadership)
Erinc Halliacli

Erinc Halliacli

Co-PI (Core Leadership)
Glenda Halliday

Glenda Halliday

Co-PI (Core Leadership)
Vikram Khurana

Vikram Khurana

Co-PI (Core Leadership)

Team Nelson

Alexandra Nelson

Alexandra Nelson

Lead PI (Core Leadership)
Zayd Khaliq

Zayd Khaliq

Co-PI (Core Leadership)
Talia Lerner

Talia Lerner

Co-PI (Core Leadership)
Elie Matar

Elie Matar

Co-PI (Core Leadership)

Team Vila

Miquel Vila

Miquel Vila

Lead PI (Core Leadership)
Glenda Halliday

Glenda Halliday

Co-PI (Core Leadership)
Nicola Mercuri

Nicola Mercuri

Co-PI (Core Leadership)
Jose Obeso

Jose Obeso

Co-PI (Core Leadership)
Matthias Prigge

Matthias Prigge

Co-PI (Core Leadership)
Javier Hoyo Perez

Javier Hoyo Perez

Project Manager

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