Background pattern of a brain with neural connections

Team Halliday

A Global Brainbank to Identify Data-Driven Molecular and Cellular Subtyping Underlying Disease Initiation and Progression in Lewy Body Diseases

2026-Present

Parkinson’s disease (PD) is different for everyone, with some experiencing early-onset, faster progression or co-pathology, like Alzheimer’s proteins. This global initiative leverages large Brain Bank cohorts to understand why and how these differences occur. We will apply artificial intelligence and advanced lab techniques to investigate how distinct brain cells and proteins contribute to the development and progression of PD. The goal is to identify specific disease subtypes, find early warning signs, and discover new treatment targets. By mapping these patterns, we hope to define biological subtypes to improve diagnosis, determine early pathologies for targeting, and identify drivers of pathological progression.

Tags
Machine learningNeurodegenerationPathologyPD progressionPD subtypesTranscriptomics

Contributions

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Accolades

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In the News

Decoding the Blueprint: Advancing Personalized Parkinson’s Treatments

Decoding the Blueprint: Advancing Personalized Parkinson’s Treatments

05/21/2026 — In our community, we often hear: “If you’ve met one person with Parkinson’s, you’ve met one person with Parkinson’s.” This isn’t just an adage — it’s a biological reality. This radical variability is exactly what makes the disease so difficult to outsmart. We’ve learned that a puzzle this fragmented cannot be solved with a single, broad stroke. Our goal isn’t to find one answer for everyone, but the right answer for the right person at the right time.

Aligning Science Across Parkinson’s and The Michael J. Fox Foundation Expand Global Research Initiative with $261M Investment Toward Personalized Treatments

Aligning Science Across Parkinson’s and The Michael J. Fox Foundation Expand Global Research Initiative with $261M Investment Toward Personalized Treatments

04/28/2026 — Today, Aligning Science Across Parkinson’s (ASAP), in partnership with The Michael J. Fox Foundation for Parkinson’s Research (MJFF), announced $261 million in new grant funding for the Collaborative Research Network (CRN) to map the biological blueprint of Parkinson’s disease and build a standardized toolkit of global research resources that are needed to turn discoveries into treatments.

Our Research Teams

Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.