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Team Krichevsky
RNA Mechanisms of Resilience and Vulnerability in Aging and Parkinson’s Disease
Reasons underlying differential neuronal vulnerability and phenotypic penetrance in Parkinson’s disease (PD) remain poorly explained. We investigate how RNA, a key modulator of cell function, influences brain resilience in aging and PD. We examine how dysregulation of protein-coding and regulatory RNA contributes to alpha-synuclein (aS) and tau proteinopathies, both considered important in PD. We propose dissecting these mechanisms in iPSC-derived models with correlation to i) changes in brain regions exhibiting high resilience to aS and ii) genetic factors underlying PD risk and progression. Understanding these mechanisms could lead to targeted genetic therapies that enhance neuronal survival and slow PD progression.
Tags
Alpha-synucleinin situ RNA analyticsiPSC neuronsNon-coding RNA
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