David Sulzer
Lead PI (Core Leadership)
Columbia University
Dr. David Sulzer is a Professor in the Departments of Psychiatry, Neurology, Pharmacology and the School of the Arts at Columbia University. He studied synaptic vesicle recycling with Eric Holtzman at Columbia University. He founded the Dopamine Society (with Louis-Eric Trudeau), the journal Nature Parkinson’s Disease (with Ray Chaudhuri) and the Gordon Conference on Parkinson’s disease.
Recent ASAP Preprints & Published Papers
Interaction of an α-synuclein epitope with HLA-DRB1*15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s disease
Enteric symptoms, including constipation, are hallmarks of prodromal Parkinson’s disease (PD) that can appear decades before the onset of motor symptoms and diagnosis. PD patients possess circulating T cells that recognize specific α-synuclein-(α-syn)-derived epitopes. One epitope, α-syn32-46, binds with strong affinity to the HLA-DRB1*15:01 allele implicated in autoimmune diseases. We…
Conserved and cell type-specific transcriptional responses to IFN-γ in the ventral midbrain
Dysregulated inflammation within the central nervous system (CNS) contributes to neuropathology in infectious, autoimmune, and neurodegenerative disease. With the exception of microglia, major histocompatibility complex (MHC) proteins are virtually undetectable in the mature, healthy central nervous system (CNS). Neurons have generally been considered incapable of antigen presentation, and although interferon…
