Enrico Bagnoli
Project Manager
University of Dundee
Enrico recently joined the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee. He completed a PhD in Neuroscience at the National University of Ireland, Galway working on novel organotypic model of prodromal Parkinson’s disease. Before moving to Ireland and to the field of Neuroscience, Enrico obtained a Master and Bachelor degree in Bioengineering from the University of Genoa, Italy, working on tunable and biodegradable nanodelivery system for cancer therapy.
Recent ASAP Preprints & Published Papers
Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain
Mutations in Leucine-rich repeat kinase 2 (LRRK2) and PTEN-induced kinase 1 (PINK1) are associated with familial Parkinson’s disease (PD). LRRK2 phosphorylates Rab guanosine triphosphatase (GTPases) within the Switch II domain while PINK1 directly phosphorylates Parkin and ubiquitin (Ub) and indirectly induces phosphorylation of a subset of Rab GTPases. Herein we…
Tagless LysoIP for immunoaffinity enrichment of native lysosomes from clinical samples
Lysosomes are implicated in a wide spectrum of human diseases including monogenic lysosomal storage disorders (LSDs), age-associated neurodegeneration and cancer. Profiling lysosomal content using tag-based lysosomal immunoprecipitation (LysoTagIP) in cell and animal models allowed major discoveries in the field, however studying lysosomal dysfunction in human patients remains challenging. Here, we…
