Background pattern of a brain with neural connections
Suzanne Pfeffer

Suzanne Pfeffer

Lead PI (Core Leadership)

Co-PI (Core Leadership)

Stanford University

Suzanne Pfeffer is a Professor in the Department of Biochemistry at Stanford University School of Medicine. She studied synaptic vesicle recycling as a graduate student with Regis Kelly at UCSF and membrane trafficking with James Rothman as a postdoc at Stanford. She is a Fellow of the American Academy of Arts and Sciences, the American Association for the Advancement of Science, the American Society for Cell Biology (ASCB), and Past President of ASCB and the American Society for Biochemistry and Molecular Biology.

Teams

Alessi Pfeffer

Themes

PD Functional Genomics PD Heterogeneity

Tags

Ciliogenesis LRRK2 Lysosomes PINK1 Rab GBA (Glucocerebrosidase) Rab GTPases Cell biology Neuroprotective/regenerative Lysosomal dysfunction Endolysosomal dysfunction LRRK2 pathway PD heterogeneity: clearance

Recent ASAP Preprints & Published Papers

Selective loss of Primary Cilia and Neurotrophic Signaling in G51D α-Synuclein Mice Highlights a Common Pathway to Parkinson’s Disease

Parkinson’s disease is characterized by dopaminergic neuron loss and accumulation of α-synuclein aggregates in the brain. G51D α-synuclein knock-in mice provide a genetically and clinically relevant model of disease, exhibiting early olfactory deficits, age-dependent motor impairment, and progressive phospho-α-synuclein accumulation. In multiple Parkinson’s disease models, striatal cholinergic and parvalbumin interneurons,…

Convergent molecular pathways to inherited Parkinson's disease

The most common, high-risk genetic factors for Parkinson's disease are pathogenic *LRRK2* variants that increase LRRK2 kinase activity and pathogenic *GBA1* variants that reduce lysosomal glucocerebrosidase activity. LRRK2 phosphorylates a subset of Rab GTPases, enabling them to bind phosphorylation-specific effectors that drive cellular pathology. To date, LRRK2 has at least two major cellular roles:…

Team Alessi

Dario Alessi

Dario Alessi

Lead PI (Core Leadership)
Monther Abu-Remaileh

Monther Abu-Remaileh

Co-PI (Core Leadership)
Miratul Muqit

Miratul Muqit

Co-PI (Core Leadership)
Suzanne Pfeffer

Suzanne Pfeffer

Co-PI (Core Leadership)
Enrico Bagnoli

Enrico Bagnoli

Project Manager

Team Pfeffer

Suzanne Pfeffer

Suzanne Pfeffer

Lead PI (Core Leadership)
Monther Abu-Remaileh

Monther Abu-Remaileh

Co-PI (Core Leadership)
Dario Alessi

Dario Alessi

Co-PI (Core Leadership)
Esther Sammler

Esther Sammler

Co-PI (Core Leadership)
Raja Sekhar Nirujogi

Raja Sekhar Nirujogi

Co-PI (Core Leadership)
Sreeja Vijayan Nair

Sreeja Vijayan Nair

Project Manager
Toan Khoi Quoc Phung

Toan Khoi Quoc Phung

Data Manager

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