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Our recent work points to convergent pathways for the mechanisms by which LRRK2, GBA1, PINK1 and SNCA mutations are linked to PD. We propose to investigate pathway convergence by comparing the consequences of LRRK2, GBA1, and SNCA mutations in lysosomal stress and Hedgehog signaling pathways in mouse and human brain. We focus on cell type-specific vulnerability across brain regions implicated in non-motor symptoms: the PPN and piriform cortex. We hypothesize that loss of Hedgehog signaling contributes to both motor and non-motor PD symptoms. We will also develop the first PD relevant proteomic, lipidomic and phospho-lysosome atlas for human brain and blood.
Leadership
Suzanne Pfeffer
Lead PI (Core Leadership)
Monther Abu-Remaileh
Co-PI (Core Leadership)
Dario Alessi
Co-PI (Core Leadership)
Esther Sammler
Co-PI (Core Leadership)
Raja Sekhar Nirujogi
Co-PI (Core Leadership)
Sreeja Vijayan Nair
Project Manager
Toan Khoi Quoc Phung
Data Manager
Discovery Fellows
Prosenjit Pal
Discovery Fellow
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Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.