Background pattern of a brain with neural connections
Frank Soldner

Frank Soldner

Co-PI (Core Leadership)

Albert Einstein College of Medicine

Frank is Assistant Professor in the Departments of Neuroscience and Genetics and a member of the Ruth L. and David S. Gottesman Institute for Stem Cell Biology and Regenerative Medicine at Albert Einstein College of Medicine. He received his MD from the University of Tübingen in Germany. For his thesis under the guidance of Jörg Schulz he investigated the molecular mechanism of cellular death in dopaminergic neurons as model for Parkinson’s disease. In his postdoctoral research with Ron McKay at NINDS/NIH and Rudolf Jaenisch at the Whitehead Institute at MIT, he established novel human pluripotent stem cell (hPSC)-based experimental paradigms to dissect the genetic basis of Parkinson’s disease.

Teams

Rio

Themes

PD Functional Genomics

Tags

Animal Drosphila

Recent ASAP Preprints & Published Papers

Comparison of Alternative pre-mRNA Splicing and Gene Expression Patterns in Midbrain Lineage Cells Carrying Familial Parkinson’s Disease Mutations

Parkinson’s disease (PD) is a devastating neurodegenerative disorder, with both genetic and environmental causes. Human genetic studies have identified ∼20 inherited familial genes that cause monogenic forms of PD. We have investigated the effects of individual familial PD mutations by developing a medium-throughput platform using genome-editing to install individual PD…

iSCORE-PD: an isogenic stem cell collection to research Parkinson Disease

Parkinson's disease (PD) is a neurodegenerative disorder caused by complex genetic and environmental factors. Genome-edited human pluripotent stem cells (hPSCs) offer the uniique potential to advance our understanding of PD etiology by providing disease-relevant cell-types carrying patient mutations along with isogenic control cells. To facilitate this experimental approach, we generated…

Team Rio

Donald Rio

Donald Rio

Lead PI (Core Leadership)
Helen Bateup

Helen Bateup

Co-PI (Core Leadership)
Dirk Hockemeyer

Dirk Hockemeyer

Co-PI (Core Leadership)
Frank Soldner

Frank Soldner

Co-PI (Core Leadership)

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Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.

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