Background pattern of a brain with neural connections
Johannes Jungverdorben

Johannes Jungverdorben

Project Manager

Memorial Sloan Kettering Cancer Center

Johannes Jungverdorben, PhD, is a Senior Research Scientist and program manager for Team Studer for ASAP at Memorial Sloan Kettering Cancer Center. He studied human iPSC-derived neuronal models of neurodegenerative diseases (namely Machado-Joseph disease/Spinocerebellar ataxia type 3) and focuses on protein homeostasis in diverse neuronal subtypes to uncover the selective vulnerability of neuronal subtypes amongst neurological disorders including Parkinson’s disease to drive the development of patient-specific tailored therapies.

Teams

Studer

Themes

Circuitry and Brain-Body Interactions

Tags

Mouse Microscopy - optical AAV (Adenoassociated Virus) Olfaction

Recent ASAP Preprints & Published Papers

Genome-wide CRISPR screen identifies neddylation as a regulator of neuronal aging and AD neurodegeneration.

Aging is the biggest risk factor for the development of Alzheimer’s disease (AD). Here, we performed a whole-genome CRISPR screen to identify regulators of neuronal age and show that the neddylation pathway regulates both cellular age and AD neurodegeneration in a human stem cell model. Specifically, we demonstrate that blocking…

Team Studer

Lorenz Studer

Lorenz Studer

Lead PI (Core Leadership)
Gist Croft

Gist Croft

Co-PI (Core Leadership)
Vikram Khurana

Vikram Khurana

Co-PI (Core Leadership)
Joseph Powell

Joseph Powell

Co-PI (Core Leadership)
Johannes Jungverdorben

Johannes Jungverdorben

Project Manager

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