Background pattern of a brain with neural connections
Nicholas Buitrago-Pocasangre

Nicholas Buitrago-Pocasangre

Project Manager

Yale University

Neuroinflammation project manager for Dr. Hafler at Yale University School of Medicine – Neurology Department.

Teams

Hafler

Themes

Neuro-Immune Interactions

Tags

Gut-brain axis Alpha-synuclein Autoimmunity Central Nervous System (CNS) Neuro-immune interactions

Recent ASAP Preprints & Published Papers

Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson′s Disease

We identified a pleocytosis in the CSF, most pronounced in patients with early PD. Single-cell RNAseq revealed increases in CSF-specific microglia-like macrophages expressing JAK-STAT and TNFα signaling signatures in prodromal PD, with a lack of T cell activation in the CSF. The CSF macrophages exhibited similar transcriptional profiles to dural…

Team Hafler

David Hafler

David Hafler

Lead PI (Core Leadership)
Sreeganga Chandra

Sreeganga Chandra

Co-PI (Core Leadership)
Rui Chang

Rui Chang

Co-PI (Core Leadership)
Noah Palm

Noah Palm

Co-PI (Core Leadership)
Ramnik Xavier

Ramnik Xavier

Co-PI (Core Leadership)
Nicholas Buitrago-Pocasangre

Nicholas Buitrago-Pocasangre

Project Manager

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Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.

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