Background pattern of a brain with neural connections
Rui Chang

Rui Chang

Co-PI (Core Leadership)

Yale University

Rui is an Assistant Professor in the Departments of Neuroscience and of Cellular and Molecular Physiology at Yale University School of Medicine. He studied the interaction between visceral organs and the brain.

Teams

Hafler

Themes

Neuro-Immune Interactions

Tags

Gut-brain axis Alpha-synuclein Autoimmunity Central Nervous System (CNS) Neuro-immune interactions

Recent ASAP Preprints & Published Papers

Single-cell transcriptomic and proteomic analysis of Parkinson’s disease Brains

We provide an extensive single cell analysis profiling nearly 80,000 brain nuclei from prefrontal cortex of late-stage Parkinson’s disease brains, demonstrate that α-synuclein pathology is inversely correlated with chaperone expression in excitatory neurons, found a selective abatement of neuron-astrocyte interactions with enhanced neuroinflammation, and augmented the study with proteomic analysis and cross-comparisons with Alzheimer’s disease datasets, providing valuable insights into the pathways of neurodegeneration and a deep definition of the underlying molecular pathology for Parkinson’s disease.

Team Hafler

David Hafler

David Hafler

Lead PI (Core Leadership)

Ramnik Xavier

Ramnik Xavier

Co-PI (Core Leadership)

Noah Palm

Noah Palm

Co-PI (Core Leadership)

Rui Chang

Rui Chang

Co-PI (Core Leadership)

Sreeganga Chandra

Sreeganga Chandra

Co-PI (Core Leadership)

Nicholas Buitrago-Pocasangre

Nicholas Buitrago-Pocasangre

Project Manager

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Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.

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