Sofia Koletsi
Project Manager
University College London
Sofia is the Project Manager for Team Schapira. Sofia is a recent Clinical Neuropsychiatry MSc graduate from King’s College London and is interested in the multidisciplinary study of neurodegenerative disorders, with a focus in better understanding the genome-microbiome axis in the cause of Parkinson disease.
Teams
Themes
Tags
Genome-microbiome interactions
GBA (Glucocerebrosidase)
Microbiome
Alpha-synuclein
Recent ASAP Preprints & Published Papers
Exploring the relationship between GBA1 host genotype and gut microbiome in the GBA1L444P/WT mouse model: Implications for Parkinson disease pathogenesis
**Background** Heterozygous variants in *GBA1* are the commonest genetic risk factor for Parkinson disease (PD) but penetrance is incomplete. *GBA1* dysfunction can cause gastrointestinal disturbances and microbiome changes in preclinical models. Mounting evidence suggests that the microbiota-gut-brain axis is potentially implicated in PD pathogenesis. Whether the gut microbiome composition is influenced by host *GBA1* genetics in heterozygosis…
Severe GBA1 variants drive the GBA-PD clinical phenotype: implications for counselling and clinical trials
**Background** Variants in the *GBA1* gene are the commonest genetic risk factor for Parkinson disease (PD). Genotype-phenotype correlations exist but with conflicting data, particularly in the cognitive domain. **Objectives** Comparing clinical phenotypes in a multicentre, international cohort incorporating GBA-PD and idiopathic PD (iPD) patients. **Methods** Patients underwent a comprehensive assessment of motor and non-motor functions.…
