Background pattern of a brain with neural connections
Sreeganga Chandra

Sreeganga Chandra

Co-PI (Core Leadership)

Yale University

Sreeganga Chandra is an Associate Professor in the Departments of Neurology and Neuroscience, Yale University. She is also the Deputy Chair for the Department of Neuroscience. Dr. Chandra did her postdoctoral training with Dr. Edward Koo at UC San Diego and Thomas Südhof at University of Texas Southwestern Medical Center. The Chandra laboratory explores two inter-related themes –synapse maintenance and neurodegeneration. In particular, the lab investigates Parkinson’s disease genes and risk alleles that encode synaptic proteins and how they impact synaptic structure, function and neuronal health.

Teams

Hafler

Themes

PD Functional Genomics

Tags

Rab Other Human Structural biology PI3KC3-C1 complex

Recent ASAP Preprints & Published Papers

Single-cell transcriptomic and proteomic analysis of Parkinson’s disease Brains

We provide an extensive single cell analysis profiling nearly 80,000 brain nuclei from prefrontal cortex of late-stage Parkinson’s disease brains, demonstrate that α-synuclein pathology is inversely correlated with chaperone expression in excitatory neurons, found a selective abatement of neuron-astrocyte interactions with enhanced neuroinflammation, and augmented the study with proteomic analysis…

A Markov random field model-based approach for differentially expressed gene detection from single-cell RNA-seq data

The development of single-cell RNA-sequencing (scRNA-seq) technologies has offered insights into complex biological systems at the single-cell resolution. In particular, these techniques facilitate the identifications of genes showing cell-type-specific differential expressions (DE). In this paper, we introduce MARBLES, a novel statistical model for cross-condition DE gene detection from scRNA-seq data.…

Team Hafler

David Hafler

David Hafler

Lead PI (Core Leadership)
Sreeganga Chandra

Sreeganga Chandra

Co-PI (Core Leadership)
Rui Chang

Rui Chang

Co-PI (Core Leadership)
Noah Palm

Noah Palm

Co-PI (Core Leadership)
Ramnik Xavier

Ramnik Xavier

Co-PI (Core Leadership)
Nicholas Buitrago-Pocasangre

Nicholas Buitrago-Pocasangre

Project Manager

Our Research Teams

Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.

Explore the Research Community