Background pattern of a brain with neural connections
Stein Aerts

Stein Aerts

Co-PI (Core Leadership)

KU Leuven

Prof. Stein Aerts has a multidisciplinary background in both bio-engineering and computer science. During his PhD he was trained in bioinformatics, and during his Postdoc he worked on the genomics of gene regulation in Drosophila. Stein’s lab focuses on deciphering the genomic regulatory code, using a combination of single-cell, machine-learning, and experimental approaches. Stein co-founded the Fly Cell Atlas consortium and generated a single-cell atlas of the ageing Drosophila brain. He holds an ERC Consolidator Grant and was awarded the 2017 Prize for Bioinformatics and Computational Science from the Biotech Fund and the 2016 Astrazeneca Foundation Award Bioinformatics.

Teams

Voet

Themes

Circuitry and Brain-Body Interactions

Tags

Disease models Protein aggregates Alpha-synuclein

Recent ASAP Preprints & Published Papers

HyDrop v2: Scalable atlas construction for training sequence-to-function models

Deciphering cis-regulatory logic underlying cell type identity is a fundamental question in biology. Single-cell chromatin accessibility (scATAC-seq) data has enabled training of sequence-to-function deep learning models allowing decoding of enhancer logic and design of synthetic enhancers. Training such models requires large amounts of high-quality training data across species, organs, development,…

CREsted: modeling genomic and synthetic cell type-specific enhancers across tissues and species

Sequence-based deep learning models have become the state of the art for the analysis of the genomic regulatory code. Particularly for transcriptional enhancers, deep learning models excel at deciphering sequence features and grammar that underlie their spatiotemporal activity. To enable end-to-end enhancer modeling and design, we developed a software and…

Team Voet

Thierry Voet

Thierry Voet

Lead PI (Core Leadership)
Stein Aerts

Stein Aerts

Co-PI (Core Leadership)
Guy Boeckxstaens

Guy Boeckxstaens

Co-PI (Core Leadership)
Christos Proukakis

Christos Proukakis

Co-PI (Core Leadership)
Bernard Thienpont

Bernard Thienpont

Co-PI (Core Leadership)
Sara Salama

Sara Salama

Project Manager

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