Background pattern of a brain with neural connections
Suzanne Pfeffer

Suzanne Pfeffer

Co-PI (Core Leadership)

Stanford University

Suzanne Pfeffer is a Professor in the Department of Biochemistry at Stanford University School of Medicine. She studied synaptic vesicle recycling as a graduate student with Regis Kelly at UCSF and membrane trafficking with James Rothman as a postdoc at Stanford. She is a Fellow of the American Academy of Arts and Sciences, the American Association for the Advancement of Science, the American Society for Cell Biology (ASCB), and Past President of ASCB and the American Society for Biochemistry and Molecular Biology.

Teams

Alessi

Themes

Neuro-Immune Interactions

Recent ASAP Preprints & Published Papers

Allosteric regulation of the Golgi-localized PPM1H phosphatase by Rab GTPases modulates LRRK2 substrate dephosphorylation in Parkinson’s disease

PM1H phosphatase reverses Parkinson’s disease-associated, Leucine Rich Repeat Kinase 2-mediated, Rab GTPase phosphorylation. We showed previously that PPM1H relies on an N-terminal amphipathic helix for Golgi membrane localization and this helix enables PPM1H to associate with liposomes *in vitro*; binding to highly curved liposomes activates PPM1H’s phosphatase activity. We show here…

Lysosomal Glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway to Parkinson’s disease

Parkinson’s disease is characterized by loss of dopamine neurons that project to the dorsal striatum, and mutations in *LRRK2* and *GBA1* are the most common genetic causes of familial Parkinson’s disease. Previously, we showed that pathogenic *LRRK2* mutations inhibit primary cilia formation in rare interneurons and astrocytes of the mouse and human dorsal striatum. This blocks…

Team Alessi

Dario Alessi

Dario Alessi

Lead PI (Core Leadership)
Monther Abu-Remaileh

Monther Abu-Remaileh

Co-PI (Core Leadership)
Miratul Muqit

Miratul Muqit

Co-PI (Core Leadership)
Suzanne Pfeffer

Suzanne Pfeffer

Co-PI (Core Leadership)
Enrico Bagnoli

Enrico Bagnoli

Project Manager

Our Research Teams

Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.

Explore the Research Community