Background pattern of a brain with neural connections
Zane Jaunmuktane

Zane Jaunmuktane

Co-PI (Core Leadership)

Key Personnel

University College London

Zane Jaunmuktane is a Clinical Lecturer and Honorary Consultant Neuropathologist at the Queen Square Brain Bank for Neurological Disorders and in the Division of Neuropathology, Department of Clinical and Movement Neurosciences, University College London. Together with colleagues, she was the first to demonstrate that under certain circumstances, amyloid-beta pathology is transmissible in humans. Zane’s main interest is in the cell-to-cell spreading and regional propagation mechanisms of misfolded proteins and how concomitant pathologies determine disease progression and symptom severity.

Teams

Hardy Voet

Themes

PD Functional Genomics

Tags

Clinical measures Alpha-synuclein Lysosomes Animal models Genetic targets Glycosphingolipids Mitophagy Pathology Single-cell eQTL

Recent ASAP Preprints & Published Papers

Large-scale visualisation of α-synuclein oligomers in Parkinson’s disease brain tissue

Parkinson’s disease (PD) is a common neurodegenerative condition characterised by the presence in the brain of large intraneuronal aggregates, known as Lewy bodies and Lewy neurites, containing fibrillar α-synuclein. According to the amyloid hypothesis, these large end-stage species form from smaller soluble protein assemblies, often termed oligomers, which are proposed…

Single-cell somatic copy number variants in brain using different amplification methods and reference genomes

The presence of somatic mutations, including copy number variants (CNVs), in the brain is well recognized. Comprehensive study requires single-cell whole genome amplification, with several methods available, prior to sequencing. Here we compare PicoPLEX with two recent adaptations of multiple displacement amplification (MDA): primary template-directed amplification (PTA) and droplet MDA,…

Team Hardy

John Hardy

John Hardy

Lead PI (Core Leadership)
Zane Jaunmuktane

Zane Jaunmuktane

Co-PI (Core Leadership)
Frances Platt

Frances Platt

Co-PI (Core Leadership)
Mina Ryten

Mina Ryten

Co-PI (Core Leadership)
Maria Grazia Spillantini

Maria Grazia Spillantini

Co-PI (Core Leadership)
June Smalley

June Smalley

Project Manager

Team Voet

Thierry Voet

Thierry Voet

Lead PI (Core Leadership)
Stein Aerts

Stein Aerts

Co-PI (Core Leadership)
Guy Boeckxstaens

Guy Boeckxstaens

Co-PI (Core Leadership)
Christos Proukakis

Christos Proukakis

Co-PI (Core Leadership)
Bernard Thienpont

Bernard Thienpont

Co-PI (Core Leadership)
Sara Salama

Sara Salama

Project Manager

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