Background pattern of a brain with neural connections

Team Keller

MOMA-PD: Modulate and Map Molecular Networks of Parkinson’s Disease Across Age, Sex, Brain Cell Types and Organisms

2026-Present

PD is linked to aging, but the molecular mechanisms remain unclear. We collected a comprehensive multi-omics dataset, integrating millions of brain and blood cells from humans, mice, and macaques. We developed efficient software solutions to analyze them at unprecedented scale, including age-, sex- or cell type specific trajectories. By combining cutting-edge machine learning we will identify key genes and small RNAs driving PD in the context of ageing, at best conserved in human, mice and non-human primates (NHPs). We will validate the cascades in human brain tissue and by functional genomics in aged and PD animal models and patient derived iPSCs.

Tags
AlgorithmsBioinformaticsData scienceFunctional genomicsmiRNASingle-cell multi-omics

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In the News

Decoding the Blueprint: Advancing Personalized Parkinson’s Treatments

Decoding the Blueprint: Advancing Personalized Parkinson’s Treatments

05/21/2026 — In our community, we often hear: “If you’ve met one person with Parkinson’s, you’ve met one person with Parkinson’s.” This isn’t just an adage — it’s a biological reality. This radical variability is exactly what makes the disease so difficult to outsmart. We’ve learned that a puzzle this fragmented cannot be solved with a single, broad stroke. Our goal isn’t to find one answer for everyone, but the right answer for the right person at the right time.

Aligning Science Across Parkinson’s and The Michael J. Fox Foundation Expand Global Research Initiative with $261M Investment Toward Personalized Treatments

Aligning Science Across Parkinson’s and The Michael J. Fox Foundation Expand Global Research Initiative with $261M Investment Toward Personalized Treatments

04/28/2026 — Today, Aligning Science Across Parkinson’s (ASAP), in partnership with The Michael J. Fox Foundation for Parkinson’s Research (MJFF), announced $261 million in new grant funding for the Collaborative Research Network (CRN) to map the biological blueprint of Parkinson’s disease and build a standardized toolkit of global research resources that are needed to turn discoveries into treatments.

Our Research Teams

Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.