Matthias Flotho

Matthias is a PhD student with Andreas Keller at Saarland University and the Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), where he works on large-scale integration and harmonization of single-nucleus and single-cell omics data across cohorts and species. His recent work includes ROSMAP-Compass, an AI-ready atlas of 22 million single nuclei from the ROSMAP cohort, and ZEBRA, a hierarchically integrated gene expression atlas of the murine and human brain. He also contributes to open-source tooling and visualization libraries for high-dimensional single-cell analysis, and to infrastructure for making cohort-scale omics resources queryable by both researchers and LLM-driven agents. He received his BSc and MSc in bioinformatics from Saarland University.