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Team Kirkeby
Connecting the environmental exposome to PD risk and disease pathology
Although many PD-associated toxicants have been banned in EU for >20 years, it is paradoxical that the increase in incidence of PD is higher in Europe than in USA. Here, we perform systematic screening of environmental toxicants in a stem cell-based model of PD and select key candidates for testing in rodents. With a team of environmental chemists, we search for novel PD-associated toxicants by screening the urine of newly diagnosed PD individuals through non-targeted exposomics, and we make use of data-rich Danish registers to identify epidemiological links between individual life-long toxicant exposure and PD diagnosis.
Tags
Environmental toxinsGene-environment interactionsiPSC neurons
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Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.
