Background pattern of a brain with neural connections
Agnete Kirkeby

Agnete Kirkeby

Lead PI (Core Leadership)

Co-PI (Core Leadership)

University of Copenhagen

Agnete is an associate professor at the Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW) at University of Copenhagen (Denmark). Her group specialises in generating specific subtypes of human neurons from stem cells as transplantation therapy for brain diseases as well as for disease modelling. Agnete and collaborators have developed a stem cell-based dopamine cell product (STEM-PD), which is now in clinical trial for Parkinson’s Disease. Agnete and her group further works on the preclinical development of stem cell therapies for treatment of dementia symptoms in Parkinson’s Disease as well as on using stem cells for modelling Parkinson’s Disease, Alzheimer’s Disease, Schizopphrenia and appetite regulation in the dish for development of novel disease-modifying therapies.

Teams

Jakobsson Kirkeby

Themes

Neuro-Immune Interactions PD Heterogeneity

Tags

Transposable elements Neuroinflammation iPSC neurons Environmental toxins PD heterogeneity: environment Gene-environment interactions

Recent ASAP Preprints & Published Papers

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson’s disease

Parkinson’s disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to inflammatory states, but their potential role in PD has not been explored. Using bulk– and single nuclei RNAseq of postmortem brain tissue from four…

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development

Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human developmental programs is lacking, in part due to the challenges associated with specific profiling and manipulation of human L1 expression. Here we show that…

Team Jakobsson

Johan Jakobsson

Johan Jakobsson

Lead PI (Core Leadership)
Roger Barker

Roger Barker

Co-PI (Core Leadership)
Molly Gale Hammell

Molly Gale Hammell

Co-PI (Core Leadership)
Agnete Kirkeby

Agnete Kirkeby

Co-PI (Core Leadership)
Laura Castilla-Vallmanya

Laura Castilla-Vallmanya

Project Manager

Team Kirkeby

Agnete Kirkeby

Agnete Kirkeby

Lead PI (Core Leadership)
Per Borghammer

Per Borghammer

Co-PI (Core Leadership)
Annette Ersbøll

Annette Ersbøll

Co-PI (Core Leadership)
Nikoline Juul Nielsen

Nikoline Juul Nielsen

Co-PI (Core Leadership)
Marina Romero-Ramos

Marina Romero-Ramos

Co-PI (Core Leadership)
Louise Piilgaard

Louise Piilgaard

Project Manager
Marta Bevilacqua

Marta Bevilacqua

Data Manager

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