Laura Castilla-Vallmanya
Project Manager
Lund University
Laura is a postdoctoral researcher at Lund University (Sweden). She obtained her PhD in Genetics from University of Barcelona (Spain) and has a strong background in studying human genetic variation and rare neurodevelopment disorders.
Teams
Themes
Tags
iPSCs (Induced pluripotent stem cells)
Transposable elements
CRISPR
Neuroinflammation
Aging
Epigenomics
Disease heterogeneity
PD heterogeneity: aging
Recent ASAP Preprints & Published Papers
TEsingle enables locus-specific transposable element expression analysis at single-cell resolution
Accurately assessing transposable elements (TE) expression from individual genomic TE locus remains an open problem in the field, due to the highly repetitive nature of these multi-copy sequences. These issues are compounded in single-cell and single-nucleus transcriptome experiments, where additional complications arise due to sparse read coverage and unprocessed mRNA…
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson’s disease
Parkinson’s disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to inflammatory states, but their potential role in PD has not been explored. Using bulk– and single nuclei RNAseq of postmortem brain tissue from four…
