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Team Barker
Aging and the Heterogeneity of Parkinson’s disease – The role of heterochromatin erosion
Heterochromatin is a tightly packed form of DNA that is progressively lost with age and may be key to Parkinson’s Disease (PD) pathogenesis. We hypothesise that this process is accelerated in PD, differentially affects cell types and contributes to selective vulnerability and heterogeneity of PD. We plan to characterise heterochromatin erosion at the single-cell level in post-mortem brain tissue from PD patients, using novel epigenomic technologies. These data will be mechanistically validated using unique cell-based PD-ageing models. Ultimately, this project has the potential to identify a novel pathophysiological process in PD, explaining heterogeneity and opening up new therapeutic opportunities.
Tags
AgingCRISPRDisease heterogeneityEpigenomicsiPSCs (Induced pluripotent stem cells)
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