Contributions
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Accolades
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Heterochromatin is a tightly packed form of DNA that is progressively lost with age and may be key to Parkinson’s Disease (PD) pathogenesis. We hypothesise that this process is accelerated in PD, differentially affects cell types and contributes to selective vulnerability and heterogeneity of PD. We plan to characterise heterochromatin erosion at the single-cell level in post-mortem brain tissue from PD patients, using novel epigenomic technologies. These data will be mechanistically validated using unique cell-based PD-ageing models. Ultimately, this project has the potential to identify a novel pathophysiological process in PD, explaining heterogeneity and opening up new therapeutic opportunities.
Leadership
Roger Barker
Lead PI (Core Leadership)
Johan Jakobsson
Co-PI (Core Leadership)
Annelies Quaegebeur
Co-PI (Core Leadership)
Lorenz Studer
Co-PI (Core Leadership)
Fides Zenk
Co-PI (Core Leadership)
Laura Castilla-Vallmanya
Project Manager
Yogita Sharma
Data Manager
Discovery Fellows
Raquel Garza
Discovery Fellow
Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.