Background pattern of a brain with neural connections

Team Barker

Aging and the Heterogeneity of Parkinson’s disease – The role of heterochromatin erosion

2026-Present

Heterochromatin is a tightly packed form of DNA that is progressively lost with age and may be key to Parkinson’s Disease (PD) pathogenesis. We hypothesise that this process is accelerated in PD, differentially affects cell types and contributes to selective vulnerability and heterogeneity of PD. We plan to characterise heterochromatin erosion at the single-cell level in post-mortem brain tissue from PD patients, using novel epigenomic technologies. These data will be mechanistically validated using unique cell-based PD-ageing models. Ultimately, this project has the potential to identify a novel pathophysiological process in PD, explaining heterogeneity and opening up new therapeutic opportunities.

Tags
AgingCRISPRDisease heterogeneityEpigenomicsiPSCs (Induced pluripotent stem cells)

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In the News

Decoding the Blueprint: Advancing Personalized Parkinson’s Treatments

Decoding the Blueprint: Advancing Personalized Parkinson’s Treatments

05/21/2026 — In our community, we often hear: “If you’ve met one person with Parkinson’s, you’ve met one person with Parkinson’s.” This isn’t just an adage — it’s a biological reality. This radical variability is exactly what makes the disease so difficult to outsmart. We’ve learned that a puzzle this fragmented cannot be solved with a single, broad stroke. Our goal isn’t to find one answer for everyone, but the right answer for the right person at the right time.

Aligning Science Across Parkinson’s and The Michael J. Fox Foundation Expand Global Research Initiative with $261M Investment Toward Personalized Treatments

Aligning Science Across Parkinson’s and The Michael J. Fox Foundation Expand Global Research Initiative with $261M Investment Toward Personalized Treatments

04/28/2026 — Today, Aligning Science Across Parkinson’s (ASAP), in partnership with The Michael J. Fox Foundation for Parkinson’s Research (MJFF), announced $261 million in new grant funding for the Collaborative Research Network (CRN) to map the biological blueprint of Parkinson’s disease and build a standardized toolkit of global research resources that are needed to turn discoveries into treatments.

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Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.