Yogita Sharma
Data Manager
Key Personnel
Lund University
Yogita is a bioinformatician working in department of Stem Cell Center, Lund University.
Teams
Themes
Tags
PD heterogeneity: aging
Disease heterogeneity
Epigenomics
Aging
Neuroinflammation
CRISPR
Transposable elements
iPSCs (Induced pluripotent stem cells)
Recent ASAP Preprints & Published Papers
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson’s disease
Parkinson’s disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to inflammatory states, but their potential role in PD has not been explored. Using bulk– and single nuclei RNAseq of postmortem brain tissue from four…
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human developmental programs is lacking, in part due to the challenges associated with specific profiling and manipulation of human L1 expression. Here we show that…
