Johan Jakobsson
Lead PI (Core Leadership)
Lund University
Johan Jakobsson is a Professor in the Department of Experimental Medical Sciences at Lund University, Sweden and the Director of the Lund Stem Cell Center. He studied gene therapy in the brain as a graduate student in Lund and performed his postdoctoral work with Didier Trono at EPFL focusing on transposable elements.
Teams
Themes
Tags
Seeding assays
PD progression
Original Research
Alpha-synuclein
LRRK2
GBA (Glucocerebrosidase)
Recent ASAP Preprints & Published Papers
A framework for efficient CRISPRi-mediated silencing of retrotransposons in human pluripotent stem cells
The published protocol describes the workflow for transcriptional silencing of transposable elements (TEs) in human induced pluripotent stem cells (hiPSCs). The protocol illustrates how to design gRNAs to target families of TEs (or a unique TE locus) and how to validate the efficiency and specificity of large-scale CRISPRi-based silencing using…
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson’s disease
Parkinson’s disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to inflammatory states, but their potential role in PD has not been explored. Using bulk– and single nuclei RNAseq of postmortem brain tissue from four…
