Molly Gale Hammell
Co-PI (Core Leadership)
Cold Spring Harbor Laboratory
Dr. Molly Gale Hammell is an Associate Professor in the Simons Center for Quantitative Biology at Cold Spring Harbor Laboratory. Prior to starting her own lab at CSHL, she studied small RNA pathways as a postdoctoral fellow in the lab of Victor Ambros at UMASS Medical School. She received a Ben Barres Early Career Acceleration award from CZI’s Neurodegeneration Challenge Network.
Recent ASAP Preprints & Published Papers
TEsingle enables locus-specific transposable element expression analysis at single-cell resolution
Accurately assessing transposable elements (TE) expression from individual genomic TE locus remains an open problem in the field, due to the highly repetitive nature of these multi-copy sequences. These issues are compounded in single-cell and single-nucleus transcriptome experiments, where additional complications arise due to sparse read coverage and unprocessed mRNA…
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson’s disease
Parkinson’s disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to inflammatory states, but their potential role in PD has not been explored. Using bulk– and single nuclei RNAseq of postmortem brain tissue from four…
