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Team Koob
Full human gene replacement mouse models of Parkinson’s Disease ASAP
We are proposing to model the human genetics of PD as closely as possible in mice. To do this, we will generate “Gene Replacement” (GR) mouse lines in which the mouse version of each of the PD-related genes prioritized by the ASAP Initiative is precisely replaced with the full human version of that gene. These GR-PD mouse models will be validated and undergo basic characterizations. The mice will be freely distributed without restrictions to researchers in both academia and pharma, to serve as next generation tools for identifying critical pathogenic mechanisms in PD and for developing and preclinically testing therapeutic approaches.
Tags
Animal modelsDisease mechanismsGenetic interactionsGenetic riskGenetic variantsGenomics
Our Research Teams
Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.
